The bestPatrick Dempseymovies and TV shows include a role in one of the most successful television shows of all time and several dramatic and romantic roles in films. Dempsey actually started his acting career with coming-of-age rom-coms likeCan’t Buy Me LoveandLoverboybefore starting to diversify his acting roles to include a mix of dramas and even horror movies to his resume. However, his true breakout role came in the most successful medical drama of all time when he starred as Dr. Dreek Shepherd inGrey’s Anatomy, a character who would earn the nickname McDreamy.

While most people knowDempsey fromGrey’s Anatomy, he parlayed that into a small career as a leading man in rom-coms, although he never reached the level of success on the big screen that he did with his role in the medical drama on the small screen.He had chances to play opposite Reese Witherspoon and Amy Adams. However, in recent years, he has worked to take on a wider variety of roles. While many will only refer to him as McDreramy, there’s a lot more to Patrick Dempsey’s movie career than that one role.

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Scream 3

Cast

Scream 3 continues the meta-horror saga with Sidney Prescott visiting a Hollywood film set for Stab 3, based on the infamous Woodsboro murders. As production unfolds, another Ghostface killer emerges, threatening Sidney and her friends amidst the backdrop of the film industry.

The third movie in theScreamfranchise saw a complete change in focus for the franchise. Already a series leaning heavily into the meta-horror aspects, this film had a movie about the murders, and that all tied into a new Ghostface arriving to terrorize everyone again (and even to kill Cotton Weary at the start of the film).The movie sees Patrick Dempsey show up as Detective Mark Kincaid, as he is investigating Cotton’s murder and looks to ask Gail Weathers (Courteney Cox) some questions about the murder.

Patrick Dempsey as Mark Kincaid alongside an image of Ghostface wielding a bloody knife

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Scream 3’s Mark Kincaid played a pretty major role in the slasher sequel, but he didn’t show up in Scream 4. 2022’s Scream alludes to what he’s up to.

The film sees Dempsey’s Kincaid join the cast of characters as one of the new heroes alongside Gail, Dewey (David Arquette), and Sidney (Neve Campbell). This also effectively changed the dynamic from young adults hunted by Ghostface to a group of adults having to survive the serial killer. While it looked like Kincaid was becoming a new regular cast member, there were 11 years between this and the fourth movie, and Dempsey’s character was written out of the series by then.

Thanksgiving 2023 Movie Poster

Thanksgiving

Originally conceived as a parody trailer in 2007’s Grindhouse, Thanksgiving is a 2023 horror-slasher film from director Eli Roth. The movie centers around a serial killer who heads to a small town in Massachusetts that creates a huge event out of Thanksgiving each year with the intent of turning the residents into the main course.

In 2007, Quentin Tarantino and Robert Rodriguez co-directed the movieGrindhouse, which was two films separated by fake exploitation movie trailers in between them. Of these trailers, two of the four were made into actual movies, with Rodriguez’sMacheteand Jason Eisener’sHobo with a Shotgun. While it took 17 years, Eli Roth finally made a third one into a movie, withThanksgiving.One of the main cast members in the horror film was Patrick Dempsey, who played Sheriff Eric Newlon.

Outbreak

This was also a rare villain turn for Dempsey.

The film has a man dressed in a Pilgrim costume with a John Carver mask starting to kill people over the Thanksgiving holiday weekend. The sheriff is helping to investigate the murders, but it is the young adults in the town who finally stumble upon the truth, and they have to fight for their lives to get out of the horrific situation alive. Critics gave the film a surprising 84% fresh Rotten Tomatoes rating, praising the humor and the over-the-top gore. This was also a rare villain turn for Dempsey.

Outbreak

Outbreak is a medical thriller directed by Wolfgang Petersen, featuring Dustin Hoffman, Rene Russo, and Morgan Freeman. The film follows U.S. Army medical personnel as they race against time to contain a deadly virus outbreak originating in Africa. As the virus spreads rapidly in a small California town, the team must navigate political and ethical challenges to prevent a nationwide catastrophe.

A decade after his start as a teen heartthrob and a decade before his breakout turn onGrey’s Anatomy, Patrick Dempsey was still trying to find his place in Hollywood as an adult actor. In 1995, he joined Dustin Hoffman, Rene Russo, Morgan Freeman, and Donald Sutherland in the medical disaster filmOutbreak. This movie followed an outbreak in Zaire that eventually made its way to a small town in California, which the government quickly quarantined and shut off from the world as they fought to find a cure.

Can’t Buy Me Love (1987) - Poster

Patrick Dempsey joined the supporting cast, along with the likes of Cuba Gooding Jr. As for Dempsey, he played one of the most critical roles in the film, as Jimbo Scott.He is an employee at an animal testing facility and steals a white-headed capuchin monkey that is host to the virus. He is infected with the virus and releases the monkey into the woods outside the Palisades, setting loose the virus and almost causing a worldwide catastrophe.Outbreakwas a surprising box office success.

Can’t Buy Me Love

Can’t Buy Me Love is a teen romantic comedy directed by Steve Rash. The movie follows high school student Ronald Miller, played by Patrick Dempsey, as he pays popular cheerleader Cindy Mancini, portrayed by Amanda Peterson, to pretend to be his girlfriend to elevate his social status. As the facade continues, their relationship and Ronald’s newfound popularity bring unexpected complications.

Many fans didn’t get to know Patrick Dempsey until he became McDreamy onGrey’s Anatomy. However, for people of a certain age, Dempsey was a teenage heartthrob in the late 1980s romantic comedy scene. His most successful film during that stage of his career was the 1987 rom-comCan’t Buy Me Love. Dempsey played Ronald Miller, a high school nerd living in Arizona. He makes a deal with a popular cheerleader to give her $1,000 to pretend to be his girlfriend to make him look “cool” and improve his standing in the town.

Dan-Aykroyd-in-Dragnet-and-Henry-Winkler-in-Night-Shift

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Soon, she helps teach him how to dress cooler, and he trades in his loyal friends for the more shallow, cool kids in the town. Soon, Cindy starts to grow attracted to him for real, while he starts to lose who he really is in the guise of being “popular.” For many rom-com fans,this was the original movie with the male lead riding off on a lawnmower with the girl of his dreams. At the Young Artist Awards, Dempsey won the Best Young Actor in a Motion Picture—Comedy.

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Dexter: Original Sin

Dexter: Original Sin explores Dexter Morgan’s early years in 1991 Miami as he transitions from student to avenging serial killer. Guided by his father, Harry, Dexter crafts a moral code and navigates a forensics internship at Miami Metro Police, all while controlling his darker impulses.

In 2024, Showtime brought back serial killer Dexter Morgan in the prequel seriesDexter: Original Sin. This series takes place 15 years before the original series started and stars Patrick Gibson as a young Dexter and Christian Slater as his father, Harry Morgan. Fans of the original series might remember that it was Harry who taught Dexter to hide the Dark Passenger within and only use his urges to kill people who deserve it, such as other serial killers and people who seem to slip by justice. This series tells that story.

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Dempsey is a nice addition to theDextercast and delivers the same great performance that fans have gotten used to over the years.

Dexter is getting his start as a forensic intern when the series starts.PatrickDempsey plays Aaron Spencer, the captain of the homicide divisionat Miami Metro Police Department, who works with Dexter’s dad, Harry. Since he was close friends with Harry, he also had a soft spot for Dexter, not knowing what kind of person the younger Morgan really was. Dempsey is a nice addition to theDextercast and delivers the same great performance that fans have gotten used to over the years.

Adam Driver and Penelope Cruz in Ferrari

Bridget Jones’s Baby

The third film in the Bridget Jones franchise, Bridget Jones’s Baby stars Renee Zellweger returning to her role as Bridget Jones, who after finding out she is unexpectedly pregnant, must determine which one of her two recent flings the baby’s father is and attempt to decide who she wants to help her raise the child when it’s born. Colin Firth, Patrick Dempsey, Jim Broadbent, and Emma Thompson also star.

In 2001, Renée Zellweger’sBridget Jones’s Diaryfeatured Bridget in a love triangle with Colin Firth and Hugh Grant. That twisted triangle continued three years later inBridget Jones: The Edge of Reason. Hugh Grant’s Daniel had thrown in the towel by the end of that second movie, and Bridget married Mark. In 2016, she was back inBridget Jones’s Baby, withPatrick Dempsey replacing Hugh Grant as newcomer Jack Qwantand Bridget divorced from Mark. However, while at Daniel’s wake, she sleeps with Jack and Mark and becomes pregnant.

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This is similar to what fans have come to expect from the franchise, from the awkward situations to the misunderstandings to Bridget ending up with Mark at the end, yet again. However, Patrick Dempsey is extremely charming in his role as Jack, and the film never veers off track by making either of the love interests unnecessarily mean or discontent. Critics praised the film,and a fourth movie will arrive in 2025, albeit without Dempsey returning. However, Hugh Grant will be back (he survived his apparent death in the last film).

4Ferrari (2023)

Piero Taruffi

Ferrariis a biopic about Enzo Ferrari’s life and career. Directed by Michael Mann, the film stars Adam Driver as Ferrari, who is in a tough spot in his life. He deals with a tragedy, the danger of losing his company, and a fractured marriage. Then, he sets off on a 1,000-mile race across Italy. Joining Driver in the cast is a list of great actors, including Penélope Cruz​​​​​, Shailene Woodley, Jack O’Connell​​​​​, and Patrick Dempsey.The latter actor plays Piero Taruffi, an Italian race car driver who raced against the Ferrari team in this long-distance race.

Ferrari Cast & Character Guide

Michael Mann’s Enzo Ferrari biopic is on its way with an impressive cast bringing the real-life racing story to life.

The race went his way, and Taruffi won the race and beat the Ferrari team while actually driving a Ferrari 315 S. While the film was set to stream on Showtime, Neon released it theatrically just in time for awards season, and it ended up receiving high praise, named one of the top ten films of 2023 by the National Board of Review. It ended up as a box office flop, although it received five Satellite Award nominations, and Michael Mann was nominated for the Golden Lion at the Venice International Film Festival.

Sweet Home Alabama

Fashion designer Melanie Carmichael is engaged to the hottest guy in town, the son of New York’s mayor. However, her past is full of secrets, including Jake, the boy she married when she was a high school student. Jake refuses to divorce her and Melanie travels to Alabama to confront her past.

In 2002,Patrick Dempsey joined Reese Witherspoon in the romantic comedySweet Home Alabama. Witherspoon plays a New York fashion designer who “escaped” from her hometown in Pigeon Creek. Alabama. She has changed her last name to hide her Southern roots and has changed herself to fit in better in the high-society scene. She is now engaged to the wealthy Andrew Hennings (Dempsey), but she is still married to her estranged husband, who she left years before but never finalized the divorce because he wouldn’t sign the papers.

She has to return to Pigeon Creek to get the divorce papers signed so she can get married, but Jake (Josh Lucas) makes things more complicated for her than she could have imagined. The movie is about the fact that someone can never really leave their family behind, and there is also a side story where Andrew, a good person, has too much baggage thanks to his family’s expectations. It is a surprising rom-com with no real bad guy but three people who have to figure out their place in life.

Enchanted

Starring Amy Adams as Giselle, Enchanted follows its heroine as she is cast out of her animated fantasy world by an evil queen, ending up in the middle of New York City where she meets Robert, a jaded lawyer who reluctantly takes the clueless Giselle in. As Giselle begins to adjust to life in the real world, and her relationship with Robert deepens, she must reconcile what she thought she wanted with where life has taken her. Patrick Dempsey, James Marsden, Idina Menzel, and Susan Sarandon also star.

Enchantedis a Disney film that pays homage to the Disney Princess animated films that came before it. It starts as an animated film with an evil Queen named Andalusia (Susan Sarandon), who will lose her power if her stepson, Prince Edward, gets married. When she learns he might marry a young woman named Giselle, she curses her to get sucked into the real world (New York City), where it moves to live action, and Prince Edward is also swept into the world. Amy Adams is Giselle, and James Marsden is Price Edward.

Enchanted: Every Disney Voice Actor Easter Egg

Enchanted is packed with Disney references, and some lesser-known Easter eggs include cameos by actors who formerly voiced Disney princesses.

However, the twist here is that Giselle falls in love with a man in the real world, aManhattan divorce attorney named Robert Philip, played by Patrick Dempsey. He does not believe in true love or happily ever after, which are the mottos that Giselle lives by, and the two have to find a way to prove to each other that they were meant to be together, even if that means Giselle giving up her dream of finding her “prince.“Enchantedreceived three Oscar nominations, all for Best Original Song, while Adams and Dempsey won “Best Kiss” at the MTV Movie Awards.

Grey’s Anatomy

Grey’s Anatomy is a medical drama series revolving around surgical interns, residents, and attendings at the fictional Grey Sloan Memorial Hospital. The show features the professional and personal lives of these medical professionals, led initially by Dr. Meredith Grey, played by Ellen Pompeo. Created by Shonda Rhimes, the series highlights the complexities of medical cases while delving into the interpersonal relationships among the hospital staff.

Grey’s Anatomyis the longest-running medical drama series in television history, with 21 seasons and counting. The show’s main star has always been Ellen Pompeo as Dr. Meredith Grey. However, this show has an ensemble cast, and the doctors and nurses who pass through the hospital have their own unique storylines, romantic relationships, and drama. Meredith has had several love interests over the show’s run, butnone have been as important as Patrick Dempsey’s Dr. Derek Shepherd.

Dempsey was part of the original cast but left the series in the eleventh season when he died following an auto accident. It was a highly tragic moment since he and Meredith had gotten married, and his death destroyed her life for a long time. It was also shocking for the audience, who had labeled him McDreamy, and the series lost one of its most beloved characters. In his time on the show,Patrick Dempseywas nominated for SAG Awards and Golden Globe Awards and won a SAG Award in 2006 with the rest of the cast.